My name is Zecheng Jiang, and I am a PhD student in Dr. Weidong Yang's lab. My primary research interests lie in the use of advanced imaging techniques, particularly super-resolution microscopy and single-molecule tracking, to study intracellular proteins. Currently, my work is centered on the Nuclear Pore Complex (NPC), a crucial gateway that regulates the transport of molecules between the nucleus and the cytoplasm. The NPC plays a vital role in maintaining cellular homeostasis, and its dysfunction is linked to various diseases. By utilizing super-resolution microscopy, I aim to map the intricate architecture of the NPC and unravel the complex mechanisms underlying its function.
In addition to structural analysis, I also employ single-molecule tracking techniques to monitor the behavior of individual proteins as they interact with the NPC. This approach provides insights into the dynamic nature of protein complexes and their role in regulating nuclear-cytoplasmic transport. My goal is to understand how these processes are coordinated at the molecular level and how they contribute to the overall signaling networks within the cell.
Through my research, I hope to bridge the gap between cell biology and molecular biology, shedding light on the intricate signaling pathways that govern cellular function. By deepening our understanding of these fundamental processes, I aspire to contribute to the development of new therapeutic strategies for diseases related to cellular transport and signaling.