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Interests

My research interests are focused on the development and application of computational methods for studying the structure, function, folding, and dynamics of proteins.  We work on problems involving the interplay between computational models in structural biology and experiments at different levels of resolution and different time scales from femtoseconds to seconds or longer.  Using computational statistical mechanics as a framework, we study solvation effects in chemistry and biophysics, and develop methods and effective potentials for simulating these systems.  Our recent work is focused on the development of novel free energy methods for modeling protein-ligand binding, allosteric conformational changes of proteins, and studying their energy and evolutionary landscapes.

Biography

1976-1980             Postdoctoral researcher, Harvard University

1976                         Ph.D. Harvard University

1970                         B.S. Reed College

Selected Awards

Alfred P. Sloan Foundation Fellow. NIH Research Career Development Award. John Simon Guggenheim Foundation Fellowship. Japan Society for the Promotion of Science Fellowship. AAAS Fellow